Celebrex (celecoxib) 200 mg starts working within 1-2 hours, with peak effects at 2-4 hours. As a COX-2 selective NSAID, it targets inflammation—the root cause of pain—rather than just masking symptoms. Most patients experience relief within hours, especially for arthritis or acute pain. For chronic conditions like osteoarthritis, daily use for several days to a week may be needed for optimal results. Effectiveness varies based on metabolism, pain severity, and individual response. Always follow your doctor’s prescribed dosage—never exceed it for faster relief. If pain persists after a few doses, consult your healthcare provider. Celebrex isn’t instant but provides consistent, long-term relief with regular use.